to make whole chromosomes find the genes!Ģ ways to annotate eukaryotic genomes: -ab initio gene finders: Work on basic biological principles: Open reading frames Consensus splice sites Met start codons …. Who Gets Sequenced?–Animal model systems: *Vertebrates Homo sapiens Pan troglodytes Mus musculus Rattus rattus Canis familiaris Bos taurus Gallus gallus Xenopus tropicalis + Fufu rubripes Tetraodon nigroviridis Orysias latipes Danio rario **Arthropods 14 Drosophila species Anopholes gambiae + Apis mellifera Ixodes - tickįor Bioinformatics, Start with: Genomics: READING genome sequences ASSEMBLY of the sequence ANNOTATION of the sequence carry out dideoxy sequencing connect seqs. Who Gets Sequenced? Models Pathogens Agriculturalsįinished Genomes *** * ** * *** ** * ** * * Choanoflaggelate –closest unicellular to animals E N D - Presentation Transcriptįor Bioinformatics, Start with Genomics: The Human Genome ANIMALS Typically, - 108 - >109 bp - Sequence with many gaps - 95+% covered After Sequencing and Assembly PROKARYOTES Typically, - >106 bp - Sequence without gaps E.
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